Poly(aspartic acid-citric acid) copolymer (PAC) is a new product of poly(carboxylic acid) scale inhibitor. The study aims to develop a “green”water treatment agent for calcium phosphate scale. The article compares the efficiency of three polymeric antiscalants, poly(aspartic acid-citricacid) copolymer (PAC), polymaleic acid (HPMA) and a compound inhibitor (PAC-HPMA), for calcium phosphate scale prevention under varyingexperimental conditions. Inhibitor concentration, calcium concentration, system pH, temperature and experimental time were varied to determinetheir influences on inhibitor performance by the static scale inhibition method. The copolymer (PAC) was characterized by FTIR,1H NMR and13C NMR. The compound inhibitor was applied in the actual circulating cooling water system. An atomic force microscope (AFM), X-ray powderdiffraction (XRD) and a scale formation process analysis were used to explore the scale inhibition mechanism. The results showed that scaleinhibition rates of PAC, HPMA and PAC-HPMA against Ca3(PO4)2were, respectively, about 23%, 41.5% and 63% when the dosage was 8 mg/Lin the experiment. The compound inhibitor showed the better inhibition performance than the above two kinds of monomers. Under the actualworking conditions, the inhibition rate of compound inhibitor was close to 100% and completely met the actual application requirements of scaleinhibitor in circulating cooling water systems. The main inhibition mechanism was the decomposition-chelation dispersion effect. The compoundinhibitor can be used as an efficient “green” scale inhibitor for calcium phosphate.