A series of amphiphilic poly(ether-anhydrides) terpolymers composed of sebacic acid, 1,3-bis(carboxyphenoxy)
propane, and poly(ethylene glycol) (PEG) were synthesized via melt-condensation polymerization. The resultant
terpolymers were characterized by 1H-nuclear magnetic resonance spectroscopy (1H-NMR), Fourier transform infrared
spectroscopy, gel permeation chromatography, X-ray diffraction, polarization optical microscope, differential scanning
calorimeter, and water contact angle. Biodegradable micelles were prepared via a precipitation method through self-emulsification. The shape of these micelles was uniform and spheric according to the atomic force microscopy and transmission electron microscopy images. The dynamic light scattering measurements indicated that the diameters of micelles were typically in the range of 118–359 nm. The results displayed the PEG-based ether-anhydride terpolymers may beof great potential as nanoscaled carriers for drug delivery system.