This paper described an integrated system with an Atomic Force Microscope designed for nanomanipulation.
Simulation of the nanomanipulation process was accomplished by estimating the interactive forces between molecules of the AFM tip and the sample based on the principle of contact mechanics. The intermolecular force and interactive force between the tip and sample are modeled by the Lennard-Jones potential and the JKR theory, respectively. Besides, stereoscopic visual feedback and force feedback are being provided. This allows user to perform  nanomanipulation in a virtual reality environment with force feedback.